研究開発
論文情報
セラクルミン®を用いた試験の論文一覧
| 吸収性 | |||
| 製剤化技術 吸収性 |
TC025 | Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277. (Fig.2) |
臨床 |
|---|---|---|---|
| TC016 | Sunagawa Y, Hirano S, Katanasaka Y, Miyazaki Y, Funamoto M, Okamura N, Hojo Y, Suzuki H, Doi O, Yokoji T, Morimoto E, Takashi T, Ozawa H, Imaizumi A, Ueno M, Kakeya H, Shimatsu A, Wada H, Hasegawa K, Morimoto T. Colloidal submicron-particle curcumin exhibits high absorption efficiency-a double-blind, 3-way crossover study. J Nutr Sci Vitaminol (Tokyo). 2015; 61 (1): 37-44. |
臨床 | |
| TC011 | Morimoto T, Sunagawa Y, Katanasaka Y, Hirano S, Namiki M, Watanabe Y, Suzuki H, Doi O, Suzuki K, Yamauchi M, Yokoji T, Miyoshi-Morimoto E, Otsuka Y, Hamada T, Imaizumi A, Nonaka Y, Fuwa T, Teramoto T, Kakeya H, Wada H, Hasegawa K. Drinkable preparation of Theracurmin exhibits high absorption efficiency–a single-dose, double-blind, 4-way crossover study. Biol Pharm Bull. 2013; 36 (11): 1708-1714. |
臨床 | |
| TC001 | Sasaki H, Sunagawa Y, Takahashi K, Imaizumi A, Fukuda H, Hashimoto T, Wada H, Katanasaka Y, Kakeya H, Fujita M, Hasegawa K, Morimoto T. Innovative preparation of curcumin for improved oral bioavailability Biol Pharm Bull. 2011; 34 (5): 660-665. |
臨床 | |
| TCJ001 | 大塚喜彦、佐々木裕樹、今泉厚、橋本正、小谷和彦、桜林郁之介 クルクミン製剤の細粒化による経口クルクミン吸収姓の向上とアルコール代謝および肝機能に及ぼす影響 日本未病システム学会雑誌 別冊. 2010; 16(2): 331-333. |
前臨床&臨床 | |
| 脳・神経 | |||
| 認知機能 | TC043 | Erken N, Dost Gunay FS, Soysal P, Isik AT. The Effect of Theracurmin on Cognitive Function in an Older Patient with Chemobrain. Clin Interv Aging. 2020 May 19;15:691-693. doi: 10.2147/CIA.S252229. eCollection 2020. |
臨床 | 認知機能 | TC025 | Small GW, Siddarth P, Li Z, Miller KJ, Ercoli L, Emerson ND, Martinez J, Wong KP, Liu J, Merrill DA, Chen ST, Henning SM, Satyamurthy N, Huang SC, Heber D, Barrio JR. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018 Mar; 26 (3): 266-277. |
臨床 |
|---|---|---|---|
| 統合失調症 | TC028 | Wynn JK, Green MF, Hellemann G, Karunaratne K, Davis MC, Marder SR. The effects of curcumin on Brain-derived neurotrophic factor and cognition in schizophrenia: A randomized controlled study. Schizophrenia Res. 2018 May; 195: 572–573. |
臨床 |
| 片頭痛 | TC024 | Abdolahi M, Tafakhori A, Togha M, Okhovat AA, Siassi F, Eshraghian MR, Esdighiyan M, Djalali M, Honarvar NM, Djalali M. The synergistic effects of ω-3 fatty acids and nano-curcumin supplementation on tumor necrosis factor (TNF)-α gene expression and serum level in migraine patients. Schizophr Res. 2018 May;195:572-573. |
臨床 |
| 肝機能 | |||
| 肝機能数値 (ALT) |
TC046 | Kuwabara Y, Hirose A, Lee HJ, Hashimoto D, Iio SI, and Takara T. Effects of Theracurmin® consumption on liver function, fatigue, and sleep: a randomized, double-blind, placebo-controlled, parallel-comparison study. Functional Food in Health and Disease 2021 11; (6): 246-269. |
臨床 | TCJ004 | 小澤瞳、鷲見芳彦、仲川清隆、今泉厚. 高吸収化クルクミン製剤の肝機能への作用 医学と薬学 2016; 73 (8): 1047-1055. |
臨床 |
|---|---|---|---|
| 吸収性 アルコール代謝 |
TCJ001 | 大塚喜彦、佐々木裕樹、今泉厚、橋本正、小谷和彦、桜林郁之介. クルクミン製剤の細粒化による経口クルクミン吸収姓の向上とアルコール代謝および肝機能に及ぼす影響 日本未病システム学会雑誌 別冊. 2010; 16(2): 331-333. |
前臨床&臨床 |
| がん | |||
| 食道がん | TC008 | Milano F, Mari L, van de Luijtgaarden W, Parikh K, Calpe S, Krishnadath KK. Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response. Front Oncol. 2013 May 29; 3: 137. |
細胞 |
|---|---|---|---|
| 前立腺癌・膀胱癌 | TC021 | Kang M, Ho JN, Kook HR, Lee S, Oh JJ, Hong SK, Lee SE, Byun SS. Theracurmin® efficiently inhibits the growth of human prostate and bladder cancer cells via induction of apoptotic cell death and cell cycle arrest. Oncol Rep. 2016 Mar; 35 (3): 1463-1472. doi org/10.3892/or.2015.4537. |
細胞 |
| 膵臓がん | TC006 | Kanai M, Otsuka Y, Otsuka K, Sato M, Nishimura T, Mori Y, Kawaguchi M, Hatano E, Kodama Y, Matsumoto S, Murakami Y, Imaizumi A, Chiba T, Nishihira J, Shibata H. A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin) in cancer patients. Cancer Chemother Pharmacol. 2013 Jun; 71 (6): 1521-1530. |
臨床 |
| 酸化ストレス/炎症 | |||
| クローン病 | TC042 | Sugimoto K, Ikeya K, Bamba S, Andoh A, Yamasaki H, Mitsuyama K, Nasuno M, Tanaka H, Matsuura A, Kato M, Ishida N, Tamura S, Takano R, Tani S, Osawa S, Nishihira J, Hanai H. Chemopreventive effects of nanopartic Highly Bioavailable Curcumin Derivative Ameliorates Crohn’s Disease Symptoms: A Randomized, Double-Blind, Multicenter Study. J Crohns Colitis.2020 May 15. doi: 10.1093/ecco-jcc/jjaa097. Online ahead of print. |
臨床 |
|---|---|---|---|
| 運動誘発性酸化ストレス | TC014 | Takahashi M, Suzuki K, Kim HK, Otsuka Y, Imaizumi A, Miyashita M, Sakamoto S. Effects of Curcumin Supplementation on Exercise-Induced Oxidative Stress in Humans. Int J Sports Med. 2014 Jun; 35 (6): 469-475. |
臨床 |
| 炎症・酸化 | TCJ003 | 鈴木克彦、泊美樹、菅間薫、北舘健太郎、三浦茂樹、吉岡浩、森有一 新規好中球機能検査法によるクルクミンの抗酸化・抗炎症作用の評価 臨床化学 別刷. 2012; 41(4): 343-348. |
細胞 |
| 筋疲労 | |||
| 筋損傷予防に効果的な摂取タイミング | TC031 | Tanabe Y, Chino K, Sagayama H, Lee HJ, Ozawa H, Maeda S, Takahashi H. Effective Timing of Curcumin Ingestion to Attenuate Eccentric Exercise-Induced Muscle Soreness in Men. J Nutr Sci Vitaminol (Tokyo). 2019; 65 (1): 82-89. doi 10.3177/jnsv.65.82. |
臨床 |
|---|---|---|---|
| TC029 | Tanabe Y, Chino K, Ohnishi T, Ozawa H, Sagayama H, Maeda S, Takahashi H. Effects of oral curcumin ingested before or after eccentric exercise on markers of muscle damage and inflammation. Scand J Med Sci Sports. 2019 Apr; 29 (4): 524-534. doi 10.1111/sms.13373. |
臨床 | |
| 筋損傷 | TC017 | Tanabe Y, Maeda S, Akazawa N, Zempo-Miyaki A, Choi Y, Ra SG, Imaizumi A, Otsuka Y, Nosaka K. Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin. Eur J Appl Physiol. 2015 Sep; 115 (9): 1949-1957. doi 10.1007/s00421-015-3170-4. |
臨床 |
| 循環器 | |||
| 動脈硬化 | TC007 | Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Effects of curcumin intake and aerobic exercise training on arterial compliance in postmenopausal women. Artery Res. 2013 Mar; 7 (1): 67-72. |
臨床 |
|---|---|---|---|
| 血管内皮機能 | TC005 | Akazawa N, Choi Y, Miyaki A, Tanabe Y, Sugawara J, Ajisaka R, Maeda S. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012 Oct; 32 (10): 795-799. |
臨床 |
| 中心動脈血圧 | TC004 | Sugawara J, Akazawa N, Miyaki A, Choi Y, Tanabe Y, Imai T, Maeda S. Effect of endurance exercise training and curcumin intake on central arterial hemodynamics in postmenopausal women: pilot study. Am J Hypertens. 2012 Jun; 25 (6): 651-656. |
臨床 |
| 心不全 | TC003 | Sunagawa Y, Wada H, Suzuki H, Sasaki H, Imaizumi A, Fukuda H, Hashimoto T, Katanasaka Y, Shimatsu A, Kimura T, Kakeya H, Fujita M, Hasegawa K, Morimoto T. A novel drug delivery system of oral curcumin markedly improves efficacy of treatment for heart failure after myocardial infarction in rats. Biol Pharm Bull. 2012; 35 (2): 139-144. |
前臨床 |
| 慢性腎障害 | TC020 | Bugyei-Twum A, Abadeh A, Thai K, Zhang Y, Mitchell M, Kabir G, Connelly KA. Suppression of NLRP3 Inflammasome Activation Ameliorates Chronic Kidney Disease-Induced Cardiac Fibrosis and Diastolic Dysfunction. Sci Rep. 2016 Dec 21; 6: 39551. |
臨床 |
| 呼吸器 | |||
| COPD (慢性閉塞性肺疾患) | TC018 | Funamoto M, Sunagawa Y, Katanasaka Y, Miyazaki Y, Imaizumi A, Kakeya H, Yamakage H, Satoh-Asahara N, Komiyama M, Wada H, Hasegawa K, Morimoto T. Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD. Int J Chron Obstruct Pulmon Dis. 2016 Aug 26; 11: 2029-2034. |
臨床 |
|---|---|---|---|
| 関節 | |||
| 変形性膝関節症 | TC045 | Pablo M, Nestor Z, Jorge L. Short-term Effectiveness of Nexala® in the Treatment of Patients with Gonarthrosis and Coxarthrosis. Jpn Pharmacol Ther 2021 49; (2): 229–238. |
臨床 |
|---|---|---|---|
| TC044 | Nakagawa Y, Mukai S, Yamada S, Murata S, Yabumoto H, Maeda T, Akamatsu S. The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders 2020 13: 1–8. doi: 10.1177/1179544120948471. |
臨床 | |
| TC026 | Shin YA, Suk MH, Jang HS, Choi HJ. Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. J Exerc Rehabil. 2017 Dec; 13 (6): 684-692. |
臨床 | |
| TC015 | Nakagawa Y, Mukai S, Yamada S, Matsuoka M, Tarumi E, Hashimoto T, Tamura C, Imaizumi A, Nishihira J, Nakamura T. Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. J Orthop Sci. 2014 Nov; 19 (6): 933-939. |
臨床 | |
| 薬物動態 | |||
| 安全性 | TC035 | Takahashi T, Iio S, Takara T. Safety Evaluation of Theracurmin® in Healthy Japanese Adults. ―A Randomized, Double—blind, Placebo—controlled Parallel—group Study― Jpn Pharmacol Thervol. 2019 Jul 1; 47(7): 1097-1113. |
臨床 |
|---|---|---|---|
| 安全性・忍容性 | TC002 | Kanai M, Imaizumi A, Otsuka Y, Sasaki H, Hashiguchi M, Tsujiko K, Matsumoto S, Ishiguro H, Chiba T. Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers. Cancer Chemother Pharmacol. 2012 Jan; 69 (1): 65-70. |
臨床 |
| 総説 | |||
| セラクルミン® | TCR004 | Imaizumi A. Highly bioavailable curcumin (Theracurmin): its development and clinical application. PharmaNutrition. 2015 Oct; 3 (4): 123–130. |
臨床 |
|---|---|---|---|
| TCR003 | Kurita T, Makino Y. Novel Curcumin Oral Delivery Systems. Anticancer Res. 2013; 33 (7): 2807-2822. |
臨床 | |
| TCR001 | Shimatsu A, Kakeya H, Imaizumi A, Morimoto T, Kanai M, Maeda S. Clinical Application of “Curcumin”, a Multi-Functional Substance. Anti-Aging Medicine . 2012 Mar; 9(2): 75-83. |
臨床 | |
| 膵臓がん | TCR002 | Kanai M. Therapeutic applications of curcumin for patients with pancreatic cancer. World J Gastroenterol. 2014 Jul; 20 (28): 9384-9391. |
臨床 |
